Iso: The New Synthetic Opioid

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Iso: The New Synthetic Opioid That Is Causing Overdose Deaths

An addictive drug that — like fentanyl — is much more powerful than morphine is causing an increasing amount of overdose deaths across the United States.

Isotonitazene, commonly referred to as “iso,” is a synthetic version of etonitazene, an opioid that’s been around since 1957.

One report says the drug is causing about 40 to 50 deaths a month in the United States. That’s up from about six per month last summer.

“Etonitazene is 1,000 times more powerful than morphine,” Dr. Yili Huang, the director of the pain management center at Northwell Health’s Phelps Hospital in New York, told Healthline. “Although isotonitazene is less potent than etonitazene that it’s derived from, it’s still more potent than fentanyl.”

“The best way to think about it is that isotonitazene is a stronger cousin of fentanyl and therefore likely even more dangerous,” Huang added.

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, more than 31,000 people died in the United States in 2018 from overdosing on synthetic opioids like fentanyl, which is typically used to treat pain in cases of advanced cancer.

Other opioids, such as oxycodone, hydrocodone, codeine, and morphine are used legally to treat pain and can be addictive. Heroin is also considered an opioid and is illegal.

Iso comes from China, Huang said, and is designed to mimic the effects of etonitazene, thereby avoiding classification in the United States until recently.

Etonitazene is classified as a schedule I controlled substance by the Drug Enforcement Administration (DEA), meaning it has high abuse potential.

Huang said there’s no current accepted medical use for etonitazene or iso in the United States. Part of the uptick in iso’s use is manufacturers responding to nations cracking down on fentanyl. China banned fentanyl and its derivatives in 2019.

“It certainly could be the new fentanyl,” Dr. Jill Thompson, the medical director at Harmony Recovery Center and Midwood Addiction Treatment in North Carolina, told Healthline. “Every few years, a new substance becomes popular for one of several reasons and it becomes the drug of choice.”

“Just as fentanyl has proven to be a highly addictive and dangerous substance, iso may actually surpass it in use and overdose rates over the next few years,” Thompson said. “Iso can be mixed with other substances, pressed into tablets, and is available in several forms.”


Source: Healthline.com & Say Cheese Tv

 

 

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